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A plane crash north of Pretoria on Tuesday afternoon has left at least 20 people injured‚ four of whom are critical‚ including the pilot‚ paramedics said.

"Initial reports show that approximately 20 people had sustained injuries ranging from minor to critical", ER24 said in an emailed statement.

Images from the scene of the incident showed the aircraft broken into multiple pieces as rescue workers helped passengers and crew out of the smoking wreckage.

"There is smoke all over and paramedics are on the scene", eNCA news quoted a local police spokesman as saying.

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The aircraft was marked "Martin's Air Charter", which was the previous name of the Dutch cargo airline Martinair.

Meiring said there were two air ambulance helicopters on the scene.

The large plane appeared to have crashed through a nearby building, the official said.

"We are not sure what happened at this stage", Rosella Passier, the Aviodrome's marketing manager, told AFP in The Hague.

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It had been due to fly to Aviodrome via east Africa, through Egypt, Croatia, Austria to the Netherlands.

According to the Aviodrome's website, it cost €350,000 (US$410,000) to make the plane "flight ready" and buy parts for the planned trip to Europe.

Civil Aviation Authority investigators were at the scene and started the process of determining the cause of the accident.

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