Barcelona face Real Madrid in El Clasico on Sunday (15:15 GMT) - but for the first time in almost 11 years, one of football's most famous rivalries will feature neither Lionel Messi nor Cristiano Ronaldo.
They host Barcelona in two weeks needing to win to ensure they have a better chance of topping the group.
While, Barcelona maintained their 100% start in this season's Champions League as they cruised to victory over Inter Milan at the Nou Camp on Wednesday in Messi's absence.
Baptista was the match victor on that occasion in a 1-0 win at Camp Nou and the Brazilian says there is life after Ronaldo for Real.
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This will be the first Clasico without Lionel Messi or Cristiano Ronaldo since December 2007.
As of Matchday 10, Barcelona holds the top spot in the Spanish league standings with 18 points, ahead of Espanyol on goal difference, while Real Madrid is in seventh place with 14 points.
Barcelona will also be without Lionel Messi, who is mending a broken right forearm.
The win left them joint top of Group B, with Inter also taking six points out of six. Only once has he been on the winning side, on April 9, 2014 when he between the sticks for Atlético in the 1-0 victory in the 2013-14 Champions League quarter-finals.
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They included excellent stops to deny Luis Suarez and Clement Lenglet, while Philippe Coutinho hit the Inter crossbar midway through the second half.
Ernesto Valverde's side would move seven points clear of Madrid in La Liga with a win this weekend, and Suarez is hopeful that his team can overcome their bitter rivals. Sunday's game is a great motivation for us.
We didn't do as much as we can.
Former Real Madrid president Ramon Calderon believes Jose Mourinho will return to the Spanish capital "sooner or later". "We have to be recognisable in the way we play, keeping the ball".
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Speaking in an exclusive interview with ESPN FC, the Atletico Madrid striker said he's looking forward to watching the match and that Barcelona are still talented enough to win without their injured superstar.