Djokovic will play Spain's Roberto Bautista Agut in today's semi-final, who beat three-time Grand Slam victor Stan Wawrinka in straight sets 6-4, 6-4.
Nadal said that he would not play in Brisbane because of a left thigh strain, prompting yet more fears over the 32-year-old's long term future in Tennis.
Bautista Agut said Friday's victory was the better of the two.
Asked if he had done too much through the week, he replied: "I wasn't the freshest, you know".
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The pair have met on 8 previous occasions, with Djokovic now holding a 7-1 lead in terms of matches won advantage.
" But I can not be more happy than I am now".
Djokovic has had to fight to get past his last two opponents in the tournament, but will still start as favourites to win the match.
It took the 33 year-old an hour and 30 minutes to overcome the Italian in straight sets.
He broke Djokovic in the very first game and after he came close to going 3-0 up, he did secure the double-break to open up a 4-1 lead.
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While in the first set, Djokovic was the dominant partner dictating terms, in the second it was Bautista Agut who pushed the top seed on the defensive.
After losing the first set on Friday evening, the seventh-seeded Spaniard prevailed in the tie-break to take the second set and began the third by breaking Djokovic's serve, reports Efe news.
Defeat saw Djokovic's 13-game winning run in Qatar come to an end, leaving the player frustrated and smashing his a racket in the second set. The Serbian has been nearly unbeatable on hard courts over the last six months, but Bautista-Agut trumped him in a tactical masterclass.
Bautista Agut awaits the victor of the match between, another player who has been making a comeback- Tomas Berdych and the Italian Marco Cecchinato.
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