The scathing slogans appeared just days after Iran's supreme leader Ayatollah Ali Khamenei said such insults should not be taken personally by USA or Israeli citizens.
The six-mile-long downtown Enghelab, or Revolution, Street was decorated with huge balloons as loudspeakers blared out nationalist songs.
Some of the protesters burned US flags.
Prices of basic foodstuffs have soared since President Donald Trump withdrew Washington from world powers' 2015 nuclear deal with Iran past year and reimposed sanctions on Tehran.
Iranian people gather during a ceremony to mark the 40th anniversary of the Islamic Revolution in Tehran, Iran February 11, 2019.
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TEHRAN, Iran (AP) - Iranians are pouring out onto the streets of Tehran and other cities and towns across the country, marking the date 40 years ago that's considered victory day in the country's 1979 Islamic Revolution.
"The presence of people in this celebration means that plots by the enemies. have been defused", Rouhani said.
Washington alleges Iran's launches defy a U.N. Security Council resolution calling on Iran to undertake no activity related to ballistic missiles capable of delivering nuclear weapons.
Journalist Mikey Kay recalled in this vein that Bolton has spoken at least eight times at rallies organised by MEK (Mojahedin-e Khalq), an Iranian dissident group which calls for regime change in Iran and is known to pay up to $50,000 per speech.
He said, "We will not let America become victorious.Iranian people have and will have some economic difficulties but we will overcome the problems by helping each other".
United Kingdom and Switzerland strike post-Brexit continuity agreement
Mr Barclay will later travel to Brussels for talks over dinner with the EU's chief negotiator Michel Barnier. But she said it also recognises the development of the UK's independent trade policy.
Mahmoud Hemmati, 35, was pushing his 68-year-old mother, Parivash Fakheri, in a wheelchair.
One sign read, "Much to the dismay of America, the revolution has reached its 40th year". "I don't think you'll have many more anniversaries to enjoy".
Ayatollah Ali Khamenei, the supreme leader, recently told military officials Europe "cannot be trusted, just like the Americans".
In January, President Hassan Rouhani said Iran was facing its worst economic crisis since the Shah was toppled.
In a tweet written on the anniversary that he also sent out in Farsi, Trump said the revolution had been a complete failure.
Cat survives after being found frozen in snow
However, her temperature remained very low. "She was essentially frozen", said Andrea Dutter, executive director, told CNN. They scooped her up and immediately drove her to the vet, which is probably what saved her life.
Pahlavi's name has been in the news often since late 2017 as some groups in Iran have called for a return of the monarchy during large nationwide demonstrations against political corruption and poor economic conditions.